6-Chloro-7-deazaguanine

6-Chloro-7-deazaguanine (compound 63) is an inactive molecule of IKK (lacking the critical 5-cyano group), targeting IKKα and IKKβ with Ki values both greater than 30 μM. IKKβ and IKKα are core molecules in the canonical and non-canonical NF-κB pathways, respectively.